I have been suffering a similar issue for the past six months. My old xbox 360 slim(3 years) began to make some horrid noises. They began as minor vibratory noises only occurring once in a while. It soon developed into a loud constant sequence of noises that fluctuated in nature(almost like a snoring person but more sporadic). presuming my old xbox was toast i decided to order a refurbished collectible r2d2 xbox 360 slim. To my surprise my new xbox began making the basic noise within a day of use. Pressing the frame or adjusting the tilt of my xbox helps, this makes me think it has to do with the frame. or a part that is not actively fitted in the refurbishing department or becomes loose after extended use. It could be that one of the disc drive's screws is loose and vibrates when active. or it could be a loose bolt or plastic piece in the frame reverberating when the console vibrates. Clearly it is something that gets overlooked in the refurbishing. A natural humming noise from a motherboard is understandable, but this level of noise is not. and pressing on the xbox should not make any change for the mother board. reorienting it would more likely make an extreme noise if this was the case, it does not, and actually fixes the problem for a short time. This could be because the loose screw is now reoriented for gravity to help stabilize it or the change in position fixes it in place for a short time. There has to be another or multiple sources of the dreaded noise. I plan to get a tool kit to take my older baby apart. Maybe i can figure out whats the issue is. and at any rate i will tighten everything down, make sure its secure, and maybe that is all that needs to be done. pressing on the edges of my xbox seems to make the most difference in noise quality. It would make a lot of sense that the refurbishing department would rush their fixes and potentially not tighten everything down as much as they need. Thanks for reading and remember this is all speculation and theory.