No and yes. NO if you want to retain use of your optical drive, there physically isn't enough room in the machine for two hard drives in addition to your SuperDrive. YES if you don't mid losing your SuperDrive in favor of a second hard drive.
The kit below allows this exact setup by providing a hard drive carrier in the shape of an optical drive that mounts where the SuperDrive once was, allowing you to instead install the secondary hard drive.
Once that is installed you can format and setup the drives in whatever configuration you choose.
Add a hard drive to your laptop by replacing the optical drive with a second hard drive. Compatible with all Unibody MacBooks and Unibody MacBook Pros (excluding MacBook Pro Retina). 9.5 mm Internal SATA Optical Bay for SATA Hard Drives. — 50+ available at 39.95 each.